HOMEOSTASIS IN HUMANS 
LIFE SCIENCES
STUDY GUIDES AND NOTES
GRADE 12

CHAPTER 8: HOMEOSTASIS IN HUMANS

8.1 Introduction

Homeostasis is the process of maintaining a constant internal environment within the body. The internal environment refers to the blood and tissue fluid that surrounds the cells of the body. Homeostasis enables the body to function efficiently, despite changes that might occur in the external or internal environment.
Changes in temperature, glucose levels, carbon dioxide levels, water levels and salt levels of the internal environment affects the homeostatic balance of the body. Negative feedback mechanisms operate in the human body to detect changes or imbalances in the internal environment and to restore the balance.

8.2 Negative feedback mechanisms

General sequence of events in a negative feedback mechanism :

Step 1:  An imbalance is detected.
Step 2:  A control centre is stimulated.
Step 3:  Control centre responds.
Step 4:  Message sent to target organs/s.
Step 5:  The target organ responds.
Step 6:  It opposes/reverses the imbalance.
Step 7:  Balance is restored.

8.2.1 The regulation of glucose levels in the internal environment

When the glucose level in the blood increases above normal levels:

Step 1

Glucose levels in the blood increase above normal levels

Step 2

The pancreas is stimulated

Step 3

to secrete insulin into the blood

Step 4

Insulin travels in the blood to the liver

Step 5

where it stimulates the conversion of excess glucose to glycogen which is then stored

Step 6

The glucose level in the blood now decreases

Step 7

and returns to normal

 

When the glucose level in the blood decreases below normal levels:

Step 1

Glucose levels in the blood decrease below normal levels

Step 2

The pancreas is stimulated

Step 3

to secrete glucagon into the blood

Step 4

Glucagon travels in the blood to the liver

Step 5

where it stimulates the conversion of stored glycogen to glucose

Step 6

The glucose level in the blood now increases

Step 7

and returns to normal

homeostasis 1

Figure 8.1 Negative feedback mechanism to regulate the glucose levels

8.2.2 The regulation of carbon dioxide levels in the internal environment

When the CO2 level in the blood increases above normal levels:

Step 1

CO2 levels in the blood increase above normal levels

Step 2

Receptor cells in the carotid artery in the neck are stimulated

Step 3

To send impulses to the medulla oblongata in the brain

Step 4

Medulla oblongata stimulates breathing muscles (intercostal muscles and diaphragm) and heart

Step 5

Breathing muscles contract more actively - increases the rate and depth of breathing. The heart beats faster.

Step 6

More CO2 is taken to and exhaled from the lungs

Step 7

The CO2 level in the blood returns to normal

8.2.3 The regulation of water balance in the internal environment (osmoregulation)

When the blood has less water than normal:

Step 1

Blood has less water than normal

Step 2

The hypothalamus is stimulated

Step 3

and sends impulses to the pituitary gland  to secrete more ADH

Step 4

ADH travels in the blood to the kidneys

Step 5

ADH increases the permeability of the collecting ducts and the distal convoluted tubules of

the kidney

Step 6

More water is re-absorbed and passed to the surrounding blood vessels

Step 7

The water level in the blood returns to normal

 

When the blood has more water than normal:

Step 1

Blood has more water than normal

Step 2

The hypothalamus is stimulated

Step 3

and sends impulses to the pituitary gland  to stop secreting ADH/to secrete less ADH

Step 4

No ADH/less ADH travels in the blood to the kidneys

Step 5

The collecting ducts and the distal convoluted tubules of the kidney become less permeable to water

Step 6

Less water is re-absorbed and passed to the surrounding blood vessels. More water is now lost

Step 7

The water level in the blood returns to normal

homeostasis 2

Figure 8.2 Negative feedback mechanism to regulate the water balance

8.2.4 The regulation of salt balance in the internal environment

When the salt level in the blood decreases:

Step 1

The salt level in the blood decreases

Step 2

Receptor cells in the afferent and efferent arterioles of the kidney detect the low salt level

Step 3

The adrenal gland is stimulated

Step 4

into secreting more aldosterone

Step 5

Aldosterone increases the re-absorption of sodium ions from the renal tubules in the kidney into the

surrounding blood vessels

Step 6

The salt level in the blood vessels increases

Step 7

and returns to normal

When the salt level in the blood increases:

Step 1

The salt level in the blood increases

Step 2

Receptor cells in the afferent and efferent arterioles of the kidney detect the high salt level

Step 3

The adrenal gland is stimulated

Step 4

to stop secreting aldosterone/to secrete less aldosterone

Step 5

This decreases the re-absorption of sodium ions from the renal tubules in the kidney into the

surrounding blood vessels

Step 6

The salt level in the blood vessels decreases

Step 7

and returns to normal

homeostasis 3

Figure 8.3 Negative feedback mechanism to regulate the salt balance

8.3 The process of temperature regulation

Temperature regulation is the control of body temperature to keep it as close to 37ºC as possible to enable the body to function normally.
Body temperature is regulated by the hypothalamus in the brain and the blood vessels and sweat glands in the skin.
Figure 8.4 below shows how the body temperature is regulated by the hypothalamus and the skin.
homeostasis 4
Figure 8.4 The homeostatic mechanism to regulate body temperature

Activity 1

Questions
1. Name the heat regulation centre in the brain. (1)
2. What happens to the blood vessels of the skin on a cold day? (1)
3. Describe how the state of the blood vessels mentioned in question 2 decreases heat loss. (4)
4. What happens to blood vessels of the skin on a hot day? (1)
5. Describe how the state of the blood vessels mentioned in question 4 increases heat loss. (4) [11]

Answers to activity 1
1. Hypothalamus✔ (1)
2. Blood vessels constrict✔/vasoconstriction (1)
3.

  • Less blood flows to the surface of the skin.✔
  • Less heat is lost from the surface of the skin.✔
  • Less blood flows to the sweat glands.✔
  • Sweat glands release less sweat.✔
  • Less evaporation of sweat.✔
  • Less cooling of the skin on a cold day.✔ (any 4)(4)

4. Blood vessels dilate✔/vasodilation (1)
5.

  • More blood flows to the surface of the skin.✔
  • More heat is lost from the surface of the skin.✔
  • More blood flows to the sweat glands.✔
  • Sweat glands release more sweat.✔
  • Evaporation of sweat✔
  • cools the skin on a hot day.✔ (any 4)(4) [11]
Last modified on Wednesday, 08 September 2021 12:06